Stephen Warren, Ph.D.

Associate Professor of Chemistry and Biochemistry

Dr. Stephen Warren

Contact Information

  • Fall 2019
    Tuesdays 9-9:50 a.m. and 4:10-5 p.m.
    Wednesdays: 4:10-5 p.m.
    Thursdays: 4:10-5 p.m.
  • +1 5093136601

Education & Curriculum Vitae

Ph.D. Medicinal Chemistry, State University of New York at Buffalo (1996)

Courses Taught


General Chemistry CHEM 101
General Chemistry Laboratory CHEM 101L
Medicines, Molecules, & You CHEM 190
Organic Chemistry CHEM 230
Organic Chemistry Laboratory CHEM 230L
Organic Chemistry II CHEM 331
Organic Chemistry II Laboratory CHEM 331L
Directed Research CHEM 390
Chemical Bibliography CHEM 471
Seminar CHEM 485
Seminar CHEM 486
Thesis CHEM 498A
Thesis CHEM 498B
Directed Research BIOL 498
Pharmacy Science Short Course CTED 1000 CE4

Publications 

Warren, GL; Do, TD; Kelley, BP; Nicholls, A; Warren, SD; “ESSENTIAL CONSIDERATIONS FOR USING PROTEIN-LIGAND STRUCTURES IN DRUG DISCOVERY”.  Drug Discovery Today, (In Press)a,b

Warren, GL; Warren, SD; “SCORING DRUG-RECEPTOR INTERACTIONS”.  Chapter 16 in Drug Design Strategies: Quantitative Approaches, Ed. by D. J. Livingstone and A. Davis, Royal Society of Chemistry, Cambridge, 2011, p. 440-457.b  DOI:10.1039/9781849733410-00440

Warren, SD; “GUIDE TO FLUORINE NMR FOR ORGANIC CHEMISTS.  BY WILLIAM R. DOLBIER, JR.”  J. Med. Chem.  52, 6503, 2009.b

Grecian, SA; Hadida, S; Warren, SD; “DIRECT SYNTHESIS OF TRIMETHYL(2-PHENOXYETHYL)SILANES FROM AROMATIC FLUORIDES”.  Tett. Lett. 46, 4683-4685, 2005.a

Trejo, A; Arzeno, H; Browner, M; Chanda, S; Cheng, S; Comer, DD; Dalrymple, SA; Dunten, P; Lafargue, J; Lovejoy, B; Freire-Moar, J; Lim, J; Mcintosh, J; Miller, J; Papp, E; Reuter, D; Roberts, R; Sanpablo, F; Saunders, J; Song, K; Villasenor, A; Warren, SD; Welch, M; Weller, P; Whiteley, PE; Zeng, L; and Goldstein, D; “DESIGN AND SYNTHESIS OF 4-AZAINDOLES AS INHIBITORS OF p38 MAP KINASE”.  J. Med. Chem. 46, 4702-4713, 2003. a

Nair, SA; Kim, MH; Warren, SD; Choi, S; Songyang, Z; Cantley, LC; and Hangauer, DG;  “IDENTIFICATION OF EFFICIENT PENTAPEPTIDE SUBSTRATES FOR THE TYROSINE KINASE pp60c-src”.  J. Med. Chem. 38, 4276-4283, 1995. a

Warren, SD; “DESIGN, SYNTHESIS, ENZYME BINDING EVALUATION, AND ANALYSIS OF PREFERRED ENZYME-COMPLEXES FOR PEPTIDE-BASED cyclicAMP-DEPENDENT PROTEIN KINASE INHIBITORS”.  Ph.D. Dissertation, State University of New York at Buffalo, 1995.c

Friedberg, JS; Tompkins, RG; Rakestraw, SL; Warren, SW; Fischman, AJ; and Yarmush, ML; "ANTIBODY-TARGETED PHOTOLYSIS:  BACTERIOCIDAL EFFECTS OF Sn(IV) CHLORIN e6-DEXTRAN-MONOCLONAL ANTIBODY CONJUGATES".  Ann. NY. Acad. Sci.  618, 383-393, 1991. a

Ali, SA; Warren, SD; Richter, KY; Badger, CC; Eary, JF; Press, OW; Krohn, KA; Bernstein, ID; and Nelp, WB;  "IMPROVING THE TUMOR RETENTION OF RADIOIODINATED ANTIBODY:  ARYL CARBOHYDRATE ADDUCTS".  Cancer Res.  50, 783s-788s, 1990. a

Warren, SD; Ali, SA; Richter, KY; and Krohn, KA;  "SYNTHESIS AND RADIOIODINATION OF TEN ARYL-CARBOHYDRATE COMPOUNDS FOR LABELING MONOCLONAL ANTIBODIES".  J. Label. Comp. Radiopharm.  28, 497-509, 1990. a

Ali, SA; Eary, JF; Warren, SD; Badger, CC; and Krohn, KA;  "SYNTHESIS  AND RADIOIODINATION OF TYRAMINE CELLOBIOSE FOR LABELING MONOCLONAL ANTIBODIES".  Nucl. Med. Biol.  15, 557-561, 1988  Int. J. Radiat. Appl. Instrum. Part B. a


"a" -Peer Reviewed;  "b" -Editor Solicited/Invited, Editor Reviewed;  "c" -Department Reviewed

ABSTRACTS & PRESENTATIONS

Warren, SD; Knapp, NR; Carlson, MA; Shelby, CA; Maul-Newby, HM; Watson, JM; Cronk, JD; “NEW ALLOSTERIC SITE INHIBITORS OF EUBACTERIAL β-CARBONIC ANHYDRASES”.  NorthWest Crystallography Workshop, Bozeman, MT, July 20-22, 2012

Engerman, EM; Miller, CM; Warren, SD; “REACTIVITY OF THE EXOCYCLIC NITROGENS’ OF 2,4,6-TRIAMINOPYRIMIDINE”.  Gonzaga’s Fall Family Weekend, Spokane, WA, October 21-23, 2011

Schwenne, KJ; Warren, SD; “     PROGRESS TOWARD THE SYNTHESIS OF 3-(4-BROMO-1h-IMIDAZOL-5-YL)PROPANEHYDROXAMIC ACID”.  66th Northwest Regional Meeting of the ACS, Portland, OR, June 26-29, 2011

Miller,CM; Carlson, MA; Knapp, NR; Sachet, ML; Langfield, A; Holden, J; Cronk, JD; Watson, J; Warren, SD; “LEAD GENERATION FOR POTENTIAL ALLOSTERIC INHIBITORS OF β–CARBONIC ANHYDRASE AND SYNTHESIS OF SUBSTITUTED PYRIMIDINE INHIBITORS”.  Oral presentation at the 19th Regional Conference on Undergraduate Research Murdock College Science Research Program, Linfield College, McMinnville, OR, Novermber 12 & 13, 2010

Miller,CM; Carlson, MA; Sachet, ML; Cronk, JD; Watson, J; Warren, SD; “SYNTHESIS OF SUBSTITUTED PYRIMIDINES AS INHIBITORS OF β–CARBONIC ANHYDRASE IN ESCHERICHIA COLI”.  Presented at the 19th Regional Conference on Undergraduate Research Murdock College Science Research Program, Linfield College, McMinnville, OR, Novermber 12 & 13, 2010

Carlson, MA; Knapp, NR; Sachet, ML; Langfield, A; Holden, J; Cronk, JD; Watson, J; Warren, SD; “LEAD GENERATION FOR POTENTIAL ALLOSTERIC INHIBITORS OF β–CARBONIC ANHYDRASE”.  Presented at the 19th Regional Conference on Undergraduate Research Murdock College Science Research Program, Linfield College, McMinnville, OR, Novermber 12 & 13, 2010

Warren, GL; Do, T; Warren, SD; “Iridium:  Prepping PDB data for use in computation chemistry software development”.  Presented at the 240th ACS National Meeting, Boston, MA, United States, August 22-26, 2010

Do, TD; Levingston, AL; Warren, SD; “Sequential one-pot syntheses of thiazoles and imidazo[2,1-b]thiazoles from amines, isothiocyanates and phenacyl bromides”.  Presented at the Joint 65th Northwest and 22nd Rocky Mountain Regional Meeting of the American Chemical Society, Pullman, WA, United States, June 20-23, 2010

Knapp, NR; Holden, J; Carlson, MA; Warren, SD; Sachet, ML; Miller, CM; Watson, J; Langfield, A; Cronk, JD.  “LEAD GENERATION FOR POTENTIAL ALLOSTERIC INHIBITORS OF β-CARBONIC ANHYDRASE”.  Presented at the Joint 65th Northwest and 22nd Rocky Mountain Regional Meeting of the American Chemical Society, Pullman, WA, United States, June 20-23, 2010

Knapp, NR; Sachet, ML; Langfield, A; Holden, J; Cronk, JD; Watson, J; Warren, SD; “LEAD GENERATION FOR POTENTIAL ALLOSTERIC INHIBITORS OF β-CARBONIC ANHYDRASE”.  Presented at the 18th Regional Conference on Undergraduate Research Murdock College Science Research Program,  Gonzaga University, Spokane, WA, October 30-31, 2009.

Do, TD; Warren, GL; Warren, SD; “IRIDIUM:  A CURATED DATABASE OF LIGAND-RECEPTOR COMPLEXES AND BINDING DATA”.  Presented at the 18th Regional Conference on Undergraduate Research Murdock College Science Research Program,  Gonzaga University, Spokane, WA, October 30-31, 2009.

Goossen, EA; Knapp, NR; Yee, DTt; Rhoads, T; Vadnais, K; Wisecup, A; Warren, SD; “SYNTHESIS OF 2,3-DIBENZYL-1,1-DIFLUOROGLYCEROL”.  Presented at the 18th Regional Conference on Undergraduate Research Murdock College Science Research Program,  Gonzaga University, Spokane, WA, October 30-31, 2009.

Oplinger, SL; Vadnais, KR; Warren, SD; “SPECTROPHOTOMETRIC ASSAYS OF LACTATE DEHYDROGENASE ACTIVITY IN THE PRESENCE OF LACTATE MIMETICS”.  Presented at the 18th Regional Conference on Undergraduate Research Murdock College Science Research Program,  Gonzaga University, Spokane, WA, October 30-31, 2009.

Knapp, NR; Sachet, ML; Langfield, A; Holden, J; Cronk, JD; Watson, J; Warren, SD; “LEAD GENERATION FOR POTENTIAL ALLOSTERIC INHIBITORS OF β-CARBONIC ANHYDRASE”.  Presented at the 8th International Conference on Carbonic Anhydrases, Florence, Italy, September 16-19, 2009

Watson, J; Warren, SD; Knapp, NR; Langfield, A; Sachet, ML; Cronk, JD; “COMPUTATIONAL AND KINETIC CHARACTERIZATION OF THE ALLOSTERIC SITE IN E. COLI  CARBONIC ANHYDRASE”.  Presented at the 8th International Conference on Carbonic Anhydrases, Florence, Italy, September 16-19, 2009

Warren, GL; Do, TD; Warren, SD;  “OF THINGS THAT ARE RARE:  IRIDIUM, DINOSAUR COPROLITE, AND HIGH QUALITY PROTEIN-LIGAND STRUCTURE DATABASES”.  Presented at the 238th ACS National Meeting, Washington, DC, August 16-20, 2009

Goossen, EA; Yee, DTt; Rhoads, TW; Vadnais, KR; Wisecup, A; Warren, SD;  “SYNTHESIS OF 3,3-DIFLUORO-3-DEOXYGLYCEROL”.  Presented at the 238th ACS National Meeting, Washington, DC, August 16-20, 2009

Goossen, EA; Yee, DTt; Rhoads, T; Vadnais, K; Wisecup, A; Warren, SD; “SYNTHESIS OF 2,3-DIBENZYL-1,1-DIFLUOROGLYCEROL”.  Presented at the 64th Northwest Regional Meeting of the American Chemical Society, NW-140, Tacoma, WA, June 28-July 1, 2009.

Do, TD; Warren, GL; Warren, SD; “IRIDIUM:  A CURATED DATABASE OF LIGAND-RECEPTOR COMPLEXES AND BINDING DATA”.  Presented at the 64th Northwest Regional Meeting of the American Chemical Society, NW-140, Tacoma, WA, June 28-July 1, 2009.

Knapp, N; Cronk, JD; Warren, SD; “VIRTUAL SCREENING USED TO FIND POTENTIAL ALLOSTERIC INHIBITORS OF BETA-CARBONIC ANHYDRASE”.  Presented at the 64th Northwest Regional Meeting of the American Chemical Society, NW-140, Tacoma, WA, June 28-July 1, 2009.

Do, T; Warren, GL; Warren, SD; “IRIDIUM:  A CURATED DATABASE OF LIGAND-RECEPTOR COMPLEXES AND BINDING DATA”.  Presented at CUP X, Santa Fe, New Mexico, March 8-11, 2009

Goossen, EA; Yee, DTt; Rhoads, T; Vadnais, K; Wisecup, A; Warren, SD; “SYNTHESIS OF 2,3-DIBENZYL-1,1-DIFLUOROGLYCEROL”.  Presented at 17th Regional Conference on Undergraduate Research Murdock College Science Research Program, University of Puget Sound, Tacoma, WA, November 7-8, 2008

Knapp, N; Warren, SD; “VIRTUAL SCREENING USED TO FIND POTENTIAL ALLOSTERIC INHIBITORS OF BETA-CARBONIC ANHYDRASE”.  Presented at 17th Regional Conference on Undergraduate Research Murdock College Science Research Program, University of Puget Sound, Tacoma, WA, November 7-8, 2008

Do, T; Warren, GL; Warren, SD; “A CURATED DATABASE OF LIGAND-RECEPTOR COMPLEXES AND THEIR BINDING DATA”.  Presented at 17th Regional Conference on Undergraduate Research Murdock College Science Research Program, University of Puget Sound, Tacoma, WA, November 7-8, 2008

Goossen, E; Yee, DTt; Warren, SD; “OPTIMIZATION OF THE SELECTIVE DEPROTECTION OF TRIISOPROPYLIDENE D-MANNITOL”.  Poster presented at 16th Regional Conference on Undergraduate Research Murdock College Science Research Program, Willamette University, Salem, OR, November 2-3, 2007

Warren, SD; McComas, DS; Ohlstrom, WR; Glass, H; Vachon, DJ; “MANAGING A RESEARCH OUTSOURCING RELATIONSHIP:  A TALE OF UNDERGRADUATE SUMMER RESEARCH”.  Presented at the 62nd Northwest Regional Meeting of the American Chemical Society, NW-184, Boise, ID, June 17-20, 2007

Ohlstrom, WR; McComas, DS; Vachon, DJ; Warren, SD; “DEVELOPMENTS TOWARD A MICROPARTICLE BASED DRUG DELIVERY SYSTEM FOR ADVANCED CHRONIC WOUND DRESSINGS”.  Presented at the 62nd Northwest Regional Meeting of the American Chemical Society, NW-134, Boise, ID, June 17-20, 2007

Warren, SD; McComas, DS; Ohlstrom, WR; Glass, H; Vachon, DJ; “MANAGING A RESEARCH OUTSOURCING RELATIONSHIP:  A TALE OF UNDERGRADUATE SUMMER RESEARCH”.  Presented at the 233rd American Chemical Society National Meeting Division of Business Development & Management Oral presentation #1066397, Chicago, IL, March 25-29, 2007

McComas, DS; Ohlstrom, WR; Vachon, DJ; Warren, SD; “DEVELOPMENTS TOWARD A MICROPARTICLE BASED DRUG DELIVERY SYSTEM FOR ADVANCED CHRONIC WOUND DRESSINGS”.  Oral presentation at 15th Regional Conference on Undergraduate Research Murdock College Science Research Program, University of Portland, Portland, OR, October 20-21, 2006

McComas, DS; Ohlstrom, WR; Vachon, DJ; Warren, SD; “DEVELOPMENTS TOWARD A MICROPARTICLE BASED DRUG DELIVERY SYSTEM FOR ADVANCED CHRONIC WOUND DRESSINGS”.  Poster presented at 15th Regional Conference on Undergraduate Research Murdock College Science Research Program, University of Portland, Portland, OR, October 20-21, 2006

Rhoads, TW; Vadnais, KR; Wisecup, A; Warren, SD; “PROGRESS TOWARD INCORPORATING FLUORINE INTO 3-CARBON UNIT ORGANIC MOLECULES”.  Poster presented at 15th Regional Conference on Undergraduate Research Murdock College Science Research Program, University of Portland, Portland, OR, October 20-21, 2006

Wisecup, A; Rhoads, T; Warren, SD; “ORGANOFLUORINE SYNTHESIS WITH 3-CARBON UNIT ORGANIC MOLECULES”.  Poster presented at 14th Regional Conference on Undergraduate Research Murdock College Science Research Program, Northwest Nazarene University, Napa, ID, November 11-12, 2005 

Grecian, SA; Hadida, S; Warren, SD; “SIMPLE AND EFFICIENT ROUTE TO NOVEL HIGHLY FUNCTIONALIZED BIPHENYL ETHERS”. 224th American Chemical Society National Meeting Division of Organic Chemistry, Abstract #721, Boston, MA, August 18-22, 2002.

Grecian, SA; Hadida, S; Warren, SD; “DIRECT SYNTHESIS OF PROTECTED PHENOLS FROM AROMATIC FLUORIDES”. 224th American Chemical Society National Meeting Division of Organic Chemistry, Abstract #722, Boston, MA, August 18-22, 2002.

Trejo, A; Arzeno, H; Browner, M; Cheng, S; Comer, DD; Dalrymple, S; Freire-Moar, J; Lim, J; Mcintosh, J; Miller, J; Myers, PL; Saunders, J; Sjogren, EB; Spellmyer, D; Warren, SD; Whiteley, PE; Zeng, L; Goldstein, DM; “4-AZAINDOLES:  NOVEL INHIBITORS OF p38 MAP KINASE”. 224th American Chemical Society National Meeting Division of Medicinal Chemistry, Abstract #302, Boston, MA, August 18-22, 2002.

Cheng, S; Comer, DD; Freire-Moar, J; Goldstein, DM; Myers, PL; Saunders, J; Sjorgren, EB; Teig, S; Warren, S; Whiteley, PE; “OXINDOLYLIDENE DERIVATIVES AS P38 MAP KINASE INHIBITORS”. 219th American Chemical Society National Meeting Division of Medicinal Chemistry, Abstract #282, San Francisco, CA, March 26-30, 2000.

Choi, S; Warren, SD; Hangauer, DG; “DEVELOPMENT OF AN INTRACELLULAR MIMETIC PROTEIN KINASE ASSAY”.  219th American Chemical Society National Meeting Division of Medicinal Chemistry, Abstract #229, San Francisco, CA, March 26-30, 2000.

Choi, S; Warren, SD; Nair, SA; and Hangauer, DG; "A NEW METHOD (STAIRE) FOR DETERMINING THE FORM OF A MULTISUBSTRATE ENZYME WHICH BINDS AN INHIBITOR:  APPLICATION TO PROTEIN KINASE INHIBITORS".  212th American Chemical Society National Meeting Division of Medicinal Chemistry, Abstract #3, Orlando, FL, August 25-29, 1996.

Choi, S; Warren, SD; Nair, SA; Lai, J; Marsilje, T; and Hangauer, DG; "AN INTRACELLULAR MIMETIC PROTEIN KINASE ASSAY AND A NEW METHOD (STAIRE) FOR DETERMINING THE MODE OF INHIBITION FOR MULTISUBSTRATE ENZYMES".  25th National Medicinal Chemistry Symposium, Ann Arbor, MI, Abstract #40, June 18-22, 1996.

Choi, S; Warren, SD; Nair, SA; and Hangauer, DG; "EFFECT OF IONIC STRENGTH, FREE Mg2+, AND NUCLEOTIDE CONCENTRATIONS ON MOLECULAR RECOGNITION OF PROTEIN KINASE INHIBITORS".  36th Annual Buffalo Medicinal Chemistry Symposium, SUNY at Buffalo, Buffalo, NY, May 21-24, 1995.

Warren, SD; Lee, B; Choi, S; Nair, SA; and Hangauer, DG; "MODIFIED ASSAY CONDITIONS AND RESULTS WITH PHOSPHOROUS CONTAINING PEPTIDE INHIBITORS OF PROTEIN KINASE A (PKA)".  American Society for Biochemistry and Molecular Biology Satellite Meeting -- Structure and Function of Protein Kinases and Phosphatases, Washington D.C., May 1994; FASEB J.  8, A1231, 1994.

Warren, SD; Lee, B; and Hangauer, DG; "BIOLOGICAL RESULTS OF PHOSPHOROUS CONTAINING PEPTIDES AS PROTEIN KINASE A INHIBITORS" .  26th Annual Graduate Student Symposium in Medicinal Chemistry, Purdue University, June 1993.

Ali, SA; Badger, CC; Eary, JF; Warren, SD; Press, OW; Krohn, KA; and Nelp, WB; "EVALUATION OF RADIOIODINATED TYRAMINE CELLOBIOSE LABELED ANTIBODY".  J. Nuc. Med.  29, 835, 1988.  Presented at the Society of Nuclear Medicine 35th Annual Meeting, San Francisco, CA, June 1988.

Ali, SA; Warren, SD; Badger, CC; Eary, JF; Press, OW; Krohn, KA; and Nelp, WB; "SYNTHESIS AND RADIOIODINATION OF ARYL-CARBOHYDRATE COMPOUNDS FOR ATTACHMENT TO MONOCLONAL ANTIBODIES".  International Radiopharmaceuticals Meetings, The Netherlands, 1988.

Ali, SA; Warren, SD; Richter, KY; Badger, CC; Eary, JF; Press, OW; Krohn, KA; Bernstein, ID; and Nelp, WB; "IMPROVING THE TUMOR RETENTION OF RADIOIODINATED ANTIBODY:  ARYL CARBOHYDRATE ADDUCTS".  The Second Conference on Radioimmunodetection and Radioimmunotherapy of Cancer, Princeton, NJ, Sept. 8-10, 1988.

Research Focus 

The world, especially the industrialized world, is facing two emerging epidemics. These epidemics will create significant medical needs that will negatively impact health care systems and the economies of the world if a proactive approach is not taken towards new solutions. One of these emerging epidemics is Type 2 Diabetes which is impacting a growing percent of our population. The other epidemic is the result of the steady increase in the average age of the population world wide (which is projected to continue) coupled to the exponential link between increasing age and the incidence of neurodegenerative disease.  Biochemical changes in the metabolism of cell types involved in both of these diseases have been noted.

Grants Received

Research Corporation Cottrell College Science Awards Grant "Synthesis of Lactate Analogs as Potential Probes for the Study of Metabolic Changes Present in Various Pathophysicological Conditions." June 2007 - June 2009.

National Science Foundation, Joanne Smieja, PI, Jeff Cronk, CoPI, Jennifer Shepherd, CoPI, Stephen Warren, CoPI, Jeffrey Watson, CoPI, PURCHASE OF A LIQUID CHROMATOGRAPH TIME-OF-FLIGHT MASS SPECTROMETER, February 2008 – January 2010.

Research Corporation Cottrell College Science Awards Grant,  Stephen Warren, Principal Investigator; SYNTHESIS OF LACTATE ANALOGS AS POTENTIAL PROBES FOR THE STUDY OF METABOLIC CHANGES PRESENT IN VARIOUS PATHOPHYSIOLOGICAL CONDITIONS.  June 2007 – June 2010.

Washington Technology Center Grant, Stephen Warren, Principal Investigator; EFFORTS TOWARD THE DEVELOPMENT OF A NANOMATERIAL-BASED DRUG DELIVERY SYSTEM FOR AN ADVANCED WOUND DRESSING.  March 2006 – June 2007.