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Investigating the effects of stiffness on epithelial ovarian cancer cell migration and proliferation
Epithelial ovarian cancer (EOC) is the leading cause of gynecological-related deaths. Mechanical signaling is known to play an important role in the proliferation and metastasis of EOC cells, but there is a gap in the study of dynamic responses of live EOC cells to mechanical inputs, such as change in stiffness of the microenvironment. This work aims to bridge that gap by investigating the microenvironment remodeling of EOC cells on substrates with various stiffnesses.
This work is supported by a 2026 Gonzaga Research Opportunity.
