Instrument: TA nanoITC
Manufacturer: TA Instruments
General Description: The TA Instruments Nano ITC is an isothermal titration calorimeter that measures heat changes during biomolecular interactions in solution. The instrument uses solid-state thermoelectric temperature control and power compensation calorimetry to detect binding events. Available in standard volume and low volume configurations, the system features flexible syringe assemblies for titrant delivery and an adiabatic shield within a vacuum chamber for thermal isolation. The calorimeter quantifies binding constants, stoichiometry, enthalpy, and entropy of molecular interactions through sequential injections or continuous titration modes. Applications include protein-ligand binding, metal ion coordination, micelle formation, and other solution-phase interactions across biochemistry, pharmaceutical development, and materials science research.