Stephen Warren, Ph.D.

Professor, Chemistry

Stephen Warren, Ph.D.

Contact Information

Education & Curriculum Vitae

Ph.D. Medicinal Chemistry, State University of New York at Buffalo (1996)

Courses Taught


General Chemistry CHEM 101
General Chemistry Laboratory CHEM 101L
Medicines, Molecules, & You CHEM 190
Organic Chemistry CHEM 230
Organic Chemistry Laboratory CHEM 230L
Organic Chemistry II CHEM 331
Organic Chemistry II Laboratory CHEM 331L
Directed Research CHEM 390
Chemical Bibliography CHEM 471
Seminar CHEM 485
Seminar CHEM 486
Thesis CHEM 498A
Thesis CHEM 498B
Directed Research BIOL 498
Pharmacy Science Short Course CTED 1000 CE4

Publications Research

Publications 

Warren, GL; Do, TD; Kelley, BP; Nicholls, A; Warren, SD; “ESSENTIAL CONSIDERATIONS FOR USING PROTEIN-LIGAND STRUCTURES IN DRUG DISCOVERY”.  Drug Discovery Today, (In Press)a,b

Warren, GL; Warren, SD; “SCORING DRUG-RECEPTOR INTERACTIONS”.  Chapter 16 in Drug Design Strategies: Quantitative Approaches, Ed. by D. J. Livingstone and A. Davis, Royal Society of Chemistry, Cambridge, 2011, p. 440-457.b  DOI:10.1039/9781849733410-00440

Warren, SD; “GUIDE TO FLUORINE NMR FOR ORGANIC CHEMISTS.  BY WILLIAM R. DOLBIER, JR.”  J. Med. Chem.  52, 6503, 2009.b

Grecian, SA; Hadida, S; Warren, SD; “DIRECT SYNTHESIS OF TRIMETHYL(2-PHENOXYETHYL)SILANES FROM AROMATIC FLUORIDES”.  Tett. Lett. 46, 4683-4685, 2005.a

Trejo, A; Arzeno, H; Browner, M; Chanda, S; Cheng, S; Comer, DD; Dalrymple, SA; Dunten, P; Lafargue, J; Lovejoy, B; Freire-Moar, J; Lim, J; Mcintosh, J; Miller, J; Papp, E; Reuter, D; Roberts, R; Sanpablo, F; Saunders, J; Song, K; Villasenor, A; Warren, SD; Welch, M; Weller, P; Whiteley, PE; Zeng, L; and Goldstein, D; “DESIGN AND SYNTHESIS OF 4-AZAINDOLES AS INHIBITORS OF p38 MAP KINASE”.  J. Med. Chem. 46, 4702-4713, 2003. a

Nair, SA; Kim, MH; Warren, SD; Choi, S; Songyang, Z; Cantley, LC; and Hangauer, DG;  “IDENTIFICATION OF EFFICIENT PENTAPEPTIDE SUBSTRATES FOR THE TYROSINE KINASE pp60c-src”.  J. Med. Chem. 38, 4276-4283, 1995. a

Warren, SD; “DESIGN, SYNTHESIS, ENZYME BINDING EVALUATION, AND ANALYSIS OF PREFERRED ENZYME-COMPLEXES FOR PEPTIDE-BASED cyclicAMP-DEPENDENT PROTEIN KINASE INHIBITORS”.  Ph.D. Dissertation, State University of New York at Buffalo, 1995.c

Friedberg, JS; Tompkins, RG; Rakestraw, SL; Warren, SW; Fischman, AJ; and Yarmush, ML; "ANTIBODY-TARGETED PHOTOLYSIS:  BACTERIOCIDAL EFFECTS OF Sn(IV) CHLORIN e6-DEXTRAN-MONOCLONAL ANTIBODY CONJUGATES".  Ann. NY. Acad. Sci.  618, 383-393, 1991. a

Ali, SA; Warren, SD; Richter, KY; Badger, CC; Eary, JF; Press, OW; Krohn, KA; Bernstein, ID; and Nelp, WB;  "IMPROVING THE TUMOR RETENTION OF RADIOIODINATED ANTIBODY:  ARYL CARBOHYDRATE ADDUCTS".  Cancer Res.  50, 783s-788s, 1990. a

Warren, SD; Ali, SA; Richter, KY; and Krohn, KA;  "SYNTHESIS AND RADIOIODINATION OF TEN ARYL-CARBOHYDRATE COMPOUNDS FOR LABELING MONOCLONAL ANTIBODIES".  J. Label. Comp. Radiopharm.  28, 497-509, 1990. a

Ali, SA; Eary, JF; Warren, SD; Badger, CC; and Krohn, KA;  "SYNTHESIS  AND RADIOIODINATION OF TYRAMINE CELLOBIOSE FOR LABELING MONOCLONAL ANTIBODIES".  Nucl. Med. Biol.  15, 557-561, 1988  Int. J. Radiat. Appl. Instrum. Part B. a


"a" -Peer Reviewed;  "b" -Editor Solicited/Invited, Editor Reviewed;  "c" -Department Reviewed

ABSTRACTS & PRESENTATIONS

Warren, SD; Knapp, NR; Carlson, MA; Shelby, CA; Maul-Newby, HM; Watson, JM; Cronk, JD; “NEW ALLOSTERIC SITE INHIBITORS OF EUBACTERIAL β-CARBONIC ANHYDRASES”.  NorthWest Crystallography Workshop, Bozeman, MT, July 20-22, 2012

Engerman, EM; Miller, CM; Warren, SD; “REACTIVITY OF THE EXOCYCLIC NITROGENS’ OF 2,4,6-TRIAMINOPYRIMIDINE”.  Gonzaga’s Fall Family Weekend, Spokane, WA, October 21-23, 2011

Schwenne, KJ; Warren, SD; “     PROGRESS TOWARD THE SYNTHESIS OF 3-(4-BROMO-1h-IMIDAZOL-5-YL)PROPANEHYDROXAMIC ACID”.  66th Northwest Regional Meeting of the ACS, Portland, OR, June 26-29, 2011

Miller,CM; Carlson, MA; Knapp, NR; Sachet, ML; Langfield, A; Holden, J; Cronk, JD; Watson, J; Warren, SD; “LEAD GENERATION FOR POTENTIAL ALLOSTERIC INHIBITORS OF β–CARBONIC ANHYDRASE AND SYNTHESIS OF SUBSTITUTED PYRIMIDINE INHIBITORS”.  Oral presentation at the 19th Regional Conference on Undergraduate Research Murdock College Science Research Program, Linfield College, McMinnville, OR, November 12 & 13, 2010

Miller,CM; Carlson, MA; Sachet, ML; Cronk, JD; Watson, J; Warren, SD; “SYNTHESIS OF SUBSTITUTED PYRIMIDINES AS INHIBITORS OF β–CARBONIC ANHYDRASE IN ESCHERICHIA COLI”.  Presented at the 19th Regional Conference on Undergraduate Research Murdock College Science Research Program, Linfield College, McMinnville, OR, November 12 & 13, 2010

Carlson, MA; Knapp, NR; Sachet, ML; Langfield, A; Holden, J; Cronk, JD; Watson, J; Warren, SD; “LEAD GENERATION FOR POTENTIAL ALLOSTERIC INHIBITORS OF β–CARBONIC ANHYDRASE”.  Presented at the 19th Regional Conference on Undergraduate Research Murdock College Science Research Program, Linfield College, McMinnville, OR, November 12 & 13, 2010

Warren, GL; Do, T; Warren, SD; “Iridium:  Prepping PDB data for use in computation chemistry software development”.  Presented at the 240th ACS National Meeting, Boston, MA, United States, August 22-26, 2010

Do, TD; Levingston, AL; Warren, SD; “Sequential one-pot syntheses of thiazoles and imidazo[2,1-b]thiazoles from amines, isothiocyanates and phenacyl bromides”.  Presented at the Joint 65th Northwest and 22nd Rocky Mountain Regional Meeting of the American Chemical Society, Pullman, WA, United States, June 20-23, 2010

Knapp, NR; Holden, J; Carlson, MA; Warren, SD; Sachet, ML; Miller, CM; Watson, J; Langfield, A; Cronk, JD.  “LEAD GENERATION FOR POTENTIAL ALLOSTERIC INHIBITORS OF β-CARBONIC ANHYDRASE”.  Presented at the Joint 65th Northwest and 22nd Rocky Mountain Regional Meeting of the American Chemical Society, Pullman, WA, United States, June 20-23, 2010

Knapp, NR; Sachet, ML; Langfield, A; Holden, J; Cronk, JD; Watson, J; Warren, SD; “LEAD GENERATION FOR POTENTIAL ALLOSTERIC INHIBITORS OF β-CARBONIC ANHYDRASE”.  Presented at the 18th Regional Conference on Undergraduate Research Murdock College Science Research Program,  Gonzaga University, Spokane, WA, October 30-31, 2009.

Do, TD; Warren, GL; Warren, SD; “IRIDIUM:  A CURATED DATABASE OF LIGAND-RECEPTOR COMPLEXES AND BINDING DATA”.  Presented at the 18th Regional Conference on Undergraduate Research Murdock College Science Research Program,  Gonzaga University, Spokane, WA, October 30-31, 2009.

Goossen, EA; Knapp, NR; Yee, DTt; Rhoads, T; Vadnais, K; Wisecup, A; Warren, SD; “SYNTHESIS OF 2,3-DIBENZYL-1,1-DIFLUOROGLYCEROL”.  Presented at the 18th Regional Conference on Undergraduate Research Murdock College Science Research Program,  Gonzaga University, Spokane, WA, October 30-31, 2009.

Oplinger, SL; Vadnais, KR; Warren, SD; “SPECTROPHOTOMETRIC ASSAYS OF LACTATE DEHYDROGENASE ACTIVITY IN THE PRESENCE OF LACTATE MIMETICS”.  Presented at the 18th Regional Conference on Undergraduate Research Murdock College Science Research Program,  Gonzaga University, Spokane, WA, October 30-31, 2009.

Knapp, NR; Sachet, ML; Langfield, A; Holden, J; Cronk, JD; Watson, J; Warren, SD; “LEAD GENERATION FOR POTENTIAL ALLOSTERIC INHIBITORS OF β-CARBONIC ANHYDRASE”.  Presented at the 8th International Conference on Carbonic Anhydrases, Florence, Italy, September 16-19, 2009

Watson, J; Warren, SD; Knapp, NR; Langfield, A; Sachet, ML; Cronk, JD; “COMPUTATIONAL AND KINETIC CHARACTERIZATION OF THE ALLOSTERIC SITE IN E. COLI  CARBONIC ANHYDRASE”.  Presented at the 8th International Conference on Carbonic Anhydrases, Florence, Italy, September 16-19, 2009

Warren, GL; Do, TD; Warren, SD;  “OF THINGS THAT ARE RARE:  IRIDIUM, DINOSAUR COPROLITE, AND HIGH QUALITY PROTEIN-LIGAND STRUCTURE DATABASES”.  Presented at the 238th ACS National Meeting, Washington, DC, August 16-20, 2009

Goossen, EA; Yee, DTt; Rhoads, TW; Vadnais, KR; Wisecup, A; Warren, SD;  “SYNTHESIS OF 3,3-DIFLUORO-3-DEOXYGLYCEROL”.  Presented at the 238th ACS National Meeting, Washington, DC, August 16-20, 2009

Goossen, EA; Yee, DTt; Rhoads, T; Vadnais, K; Wisecup, A; Warren, SD; “SYNTHESIS OF 2,3-DIBENZYL-1,1-DIFLUOROGLYCEROL”.  Presented at the 64th Northwest Regional Meeting of the American Chemical Society, NW-140, Tacoma, WA, June 28-July 1, 2009.

Do, TD; Warren, GL; Warren, SD; “IRIDIUM:  A CURATED DATABASE OF LIGAND-RECEPTOR COMPLEXES AND BINDING DATA”.  Presented at the 64th Northwest Regional Meeting of the American Chemical Society, NW-140, Tacoma, WA, June 28-July 1, 2009.

Knapp, N; Cronk, JD; Warren, SD; “VIRTUAL SCREENING USED TO FIND POTENTIAL ALLOSTERIC INHIBITORS OF BETA-CARBONIC ANHYDRASE”.  Presented at the 64th Northwest Regional Meeting of the American Chemical Society, NW-140, Tacoma, WA, June 28-July 1, 2009.

Do, T; Warren, GL; Warren, SD; “IRIDIUM:  A CURATED DATABASE OF LIGAND-RECEPTOR COMPLEXES AND BINDING DATA”.  Presented at CUP X, Santa Fe, New Mexico, March 8-11, 2009

Goossen, EA; Yee, DTt; Rhoads, T; Vadnais, K; Wisecup, A; Warren, SD; “SYNTHESIS OF 2,3-DIBENZYL-1,1-DIFLUOROGLYCEROL”.  Presented at 17th Regional Conference on Undergraduate Research Murdock College Science Research Program, University of Puget Sound, Tacoma, WA, November 7-8, 2008

Knapp, N; Warren, SD; “VIRTUAL SCREENING USED TO FIND POTENTIAL ALLOSTERIC INHIBITORS OF BETA-CARBONIC ANHYDRASE”.  Presented at 17th Regional Conference on Undergraduate Research Murdock College Science Research Program, University of Puget Sound, Tacoma, WA, November 7-8, 2008

Do, T; Warren, GL; Warren, SD; “A CURATED DATABASE OF LIGAND-RECEPTOR COMPLEXES AND THEIR BINDING DATA”.  Presented at 17th Regional Conference on Undergraduate Research Murdock College Science Research Program, University of Puget Sound, Tacoma, WA, November 7-8, 2008

Goossen, E; Yee, DTt; Warren, SD;

Research Focus 

The world, especially the industrialized world, is facing two emerging epidemics. These epidemics will create significant medical needs that will negatively impact health care systems and the economies of the world if a proactive approach is not taken towards new solutions. One of these emerging epidemics is Type 2 Diabetes which is impacting a growing percent of our population. The other epidemic is the result of the steady increase in the average age of the population world wide (which is projected to continue) coupled to the exponential link between increasing age and the incidence of neurodegenerative disease.  Biochemical changes in the metabolism of cell types involved in both of these diseases have been noted.

Grants Received

Research Corporation Cottrell College Science Awards Grant "Synthesis of Lactate Analogs as Potential Probes for the Study of Metabolic Changes Present in Various Pathophysicological Conditions." June 2007 - June 2009.

National Science Foundation, Joanne Smieja, PI, Jeff Cronk, CoPI, Jennifer Shepherd, CoPI, Stephen Warren, CoPI, Jeffrey Watson, CoPI, PURCHASE OF A LIQUID CHROMATOGRAPH TIME-OF-FLIGHT MASS SPECTROMETER, February 2008 – January 2010.

Research Corporation Cottrell College Science Awards Grant,  Stephen Warren, Principal Investigator; SYNTHESIS OF LACTATE ANALOGS AS POTENTIAL PROBES FOR THE STUDY OF METABOLIC CHANGES PRESENT IN VARIOUS PATHOPHYSIOLOGICAL CONDITIONS.  June 2007 – June 2010.

Washington Technology Center Grant, Stephen Warren, Principal Investigator; EFFORTS TOWARD THE DEVELOPMENT OF A NANOMATERIAL-BASED DRUG DELIVERY SYSTEM FOR AN ADVANCED WOUND DRESSING.  March 2006 – June 2007.