I was born in Lagos, Nigeria, and received my B.Sc. in Chemistry with a minor in Mathematics from Lewis-Clark State College in Lewiston, Idaho in May 2006. Later that year, I joined the chemistry program at the University of Texas at Dallas, and received my M.Sc. and Ph.D. degrees in Chemistry, in 2009 and 2011 respectively. My graduate research was focused on the development of novel small-molecule and nanosized probes for PARACEST MRI and luminescence applications, and this work earned the David E. Daniel Fellowship Award in recognition of excellence in molecular imaging research. After spending one year as a postdoctoral research associate in the same lab, I was selected as one of ten Madrid-MIT M+Vision Postdoctoral Research Fellows at MIT, where I conceived and managed an international research collaboration that involved the development of novel PET imaging agents for the diagnosis of cancer and the response assessment of anti-cancer therapies. I also worked on a project at the Beth Israel Medical Center, that investigated the potential of utilizing hyperpolarized 13C biological substrates for monitoring treatment response in preclinical cancer models using MR Spectroscopy. In 2015, I began a Tenure-Track position in the Chemistry and Biochemistry Department, where I currently teach upper and lower division courses in Chemistry, and perform research with undergraduates in the field of Biomedical Imaging.
Evbuomwan, O. M., Terreno, E., Aime, S., Sherry, A. D., Chapter 10: CEST and PARACEST agents for molecular imaging, in “The Chemistry of Molecular Imaging” by Nicholas Long, Wing-Tak Wong, and Edmund H. Immergut, Wiley Interscience, 2014. ISBN-13: 9781118093276.
Evbuomwan, O. M., Lee, J., Woods, M., and Sherry, A.D., The presence of fast exchanging proton species in aqueous solutions of paraCEST agents can impact rate constants measured for slower exchanging species when fitting CEST spectra to the Bloch equations, in Inorganic Chemistry, DOI: 10.1021/ic5012.
Mani, T., Opina, A., Zhao, P., Evbuomwan, O. M., Milburn, N., Tircso, G., Kumas, C., Sherry, A. D., The stereochemistry of amide side chains containing carboxyl groups influences water exchange rates in Eu-DOTA-tetraamide complexes in Journal of Biological Inorganic Chemistry 2013, 19(2), 161 – 171.
Evbuomwan, O. M., Kiefer, G., Sherry, A. D., Amphiphilic EuDOTA-tetraamide complexes form micelles with enhanced CEST sensitivity, Eur. J. Inorg. Chem. 2012, (12), 2126 – 2134.
Evbuomwan, O. M.; Merritt, M.; Kiefer, G.; Sherry, A.D., Nanoparticle-based PARACEST agents: The quenching effect of amine-functionalized silica nanoparticles on the CEST signal from surface conjugated chelates, Contrast Media & Molecular Imaging 2012, 7(1), 19 – 25.
Wu, Y; Evbuomwan, M; Melendez, M; Opina, A; Sherry, A. D., Advantages of macromolecular to nanosized chemical-exchange saturation transfer agents for MRI applications, in Future Medicinal Chemistry 2010, 2(3), 351 – 366.
Biomedical Imaging allows the non-invasive interrogation of biological processes at the cellular and molecular level. The information acquired through imaging can enhance our understanding of disease mechanisms, and could potentially aid earlier detection of diseases, and evaluation of treatments. My research endeavors are primarily focused on the development of lanthanide complexes for prostate cancer diagnosis, and image-guided tumor resection. All projects span inorganic chemistry, organic chemistry, analytical chemistry, and biomedical imaging, and would therefore introduce undergraduates at any level to the interdisciplinary nature of research. In addition to acquiring expertise with common analytical techniques such as NMR, HPLC, MS, and UV-Vis Spectrophotometry, students will learn to synthesize multi-dentate ligands and their corresponding lanthanide complexes, and evaluate their Magnetic Resonance and Optical Imaging Properties.