My place of birth is the notorious town of Tombstone, Arizona although home while growing up was Helena, Montana. It is at Carroll College in Helena that I became interested in physiology. While studying physiology at the University of North Dakota I also became interesting in teaching and as a graduate student was entrusted to teach medical students endocrine and respiratory physiology. My interests outside science includes sports, I am an avid handball player and enjoy running and participating in triathlons. I am not as adept at music but I enjoy trying to play guitar.
Articles and Abstracts
Bergren DR and DL Beckman. Pulmonary surface tension and head injury. Journal of Trauma, 15:336-337, 1975.
Bergren DR and DL Beckman. Hyperbaric oxygen and pulmonary surface tension. Aviation, Space and Environmental Medicine 46:994-995, 1975.
Beckman DL, DR Bergren and JD Sexton. Mechanism of OHP-induced pulmonary surfactant changes. Aerospace Medical Association, p. 170-171, 1975.
Beckman DL and DR Bergren. CNS and surface tension factors in hyperbaric pulmonary oxygen toxicity. Proceedings of the North Pacific Chapter Undersea Medical Society p. 23-25, 1976.
Bergren DR and DL Beckman. Sympathetic influence on pulmonary changes during OHP-exposure. Proceedings of the North Pacific Chapter Undersea Medical Society p. 19-22, 1976.
Bergren DR and DL Beckman. Alpha receptor influence on lung surfactants. Proceedings of the Western Pharmaceutical Society 19:87-90, 1976.
Bergren DR and DL Beckman. Lung compliance and cholesterol during stellate ganglion stimulation. Respiration Physiology 38:11-22, 1979.
Bergren DR, EH Vidruk and SR Sampson. Effects of prostaglandins E1 and E2 on activity in laryngeal and pharyngeal afferent fibers. Prostaglandins 17(4):649-655, 1979.
Bergren DR and SR Sampson. Characterization of intrapulmonary, rapidly-adapting receptors of guinea pigs. Respiration Physiology 47:83-95, 1982.
Bergren DR, JM Gustafson and DL Myers. Effect of prostaglandin F2ά on pulmonary rapidly-adapting receptors in the guinea pig. Prostaglandins 27:391-405, 1984.
Bergren DR and DL Myers. Leukotriene C4, rapidly-adapting receptor activity and intratracheal pressure in guinea pigs, I. Action of Leukotriene C4. Prostaglandins, Leukotrienes and Medicine 16:147-162, 1984.
Bergren DR and RJ Kincaid. Rapidly-adapting receptor activity and intratracheal pressure in guinea pigs, II. Action of aspirin and salicylic acid in antagonizing mediators of allergic asthma. Prostaglandins, Leukotrienes and Medicine 16:163-172, 1984.
Bergren DR, DL Myers and M Mohrman. Activity of rapid-adapting receptors to histamine and antigen challenge before and after sodium cromoglycate. Archives Internationales de Pharmacodynamie et de Therapie 273:88-99, 1985.
Bergren DR. Capsaicin challenge, reflex bronchoconstriction and local action of substance P. American Journal of Physiology, 254 (Regulatory Integrative Comparative Physiology 23):R845-R852, 1988.
Baumel J, J Wilson and DR Bergren. The ventilatory movements of the avian pelvis and tail: Function of the muscles of the tail region of the pigeon (Columba Livia). Journal of Experimental Biology 151:263-277, 1990.
Bergren DR, RG Townley, DL Marquardt, HE Gruber and VA Bergren. Antagonism of airway reactivity induced by ovalbumin antigen in guinea pigs by 5-amino-4-imidazolecarboxamide riboside. Journal of Allergy and Clinical Immunology, 88(4): 602-612, 1991.
Agrawal DK, DR Bergren, PJ Byorth and RG Townley. Platelet-activating factor induces non-specific desensitization to bronchodilators in guinea pigs. Journal of Pharmacology and Experimental Therapeutics, 259(1):1-7, 1991.
Sugiyama H, W Gang, VA Bergren, R Eda, DR Bergren, RJ Hopp, AK Bewtra and RG Townley. Attenuation of antigen-induced bronchoconstriction in guinea pigs by a new xanthines derivative (HWA448). International Archives of Allergy Apply Immunology, 96:206-210, 1991.
Bergren DR and DF Peterson. Identification of vagal sensory receptors in the rat lung: Are there subtypes of slowly adapting receptors? Journal of Physiology (London), 464:681-698, 1993.
Ustinova EE, Bergren D and HD Schultz. Neuropeptide depletion impairs postischemic recovery of isolated rat heart. Circulation Research 30:55-63, 1995.
Bergren, D.R., E.E. Ustinova and H.D. Schultz. Pulmonary C-fiber activation before and after peptidase inhibition in rats. Respiration Physiology 107: 99-109, 1997.
Bergren, D.R. Sensory receptor activation by mediators of defense reflexes in guinea-pig lungs. Respiration Physiology 108: 195-204, 1997.
Bergren, D.R. Chronic tobacco smoke exposure increases airway sensitivity to capsaicin in awake guinea pigs. Journal of Applied Physiology 90: 695-704, 2001.
Bergren, D.R. Chronic tobacco smoke exposure increases cough to capsaicin in awake guinea pigs. Respiration Physiology 126: 127-140, 2001.
Bergren. D.R. Enhanced lung C-fiber reactivity in sensitized guinea pigs exposed to chronic tobacco smoke exposure. Journal of Applied Physiology 91: 1645-1654, 2001.
Bergren D.R. Bombesin-like peptide release by tobacco smoke exposure in guinea pigs. Peptides 23: 919-926, 2002.
Bergren D. R. and. Rendell M. S. Depressed ventilatory reflexes after capsaicin challenge in streptozotocin-treated rats. Life Sciences 75: 2103-2116, 2004.
Bergren D.R. Lung C-fiber activation by substance P in guinea pigs. Journal of Applied Physiology 100: 1918-1927, 2006.
Bergren D.R. Effect of TRFK-5 on airway responsiveness in ovalbumin-treated guinea pigs exposed to tobacco smoke. Journal of Asthma. 44 (7): 529-534, 2007.
Bergren D.R. Tobacco smoke is an adjuvant for maintained airway sensitization in guinea pigs. Journal of Asthma. 44 (9): 723-728, 2007.
Bergren D.R. Environmental tobacco smoke exposure and airway hyperresponsiveness. Inflammation and Allergy Drug Targets. 2009 Dec; 8(5):340-7.
Belzowzki A, Bergren D, Brugler A, Hillman BG, Hillman KC, Hillman SR, Kuss B, Ngo BT, Pisarri T, Rendell MS, Thompson SL, Turner SA. The effect of vasoactive agents on post-pressure hyperemia.
Microvasc Res. 2012 Nov; 84(3):345-50.
Pavuluri S., Hanus, V., Bergren, DR. 2013. Airway plasticity after extended mainline tobacco smoke exposure in ovalbumin sensitized guinea pigs. Respiratory Physiology & Neurobiology 189: 639– 645.
Bergren D. R., Valentine J.L. Anti-anaphylactic action of nordihydroguaiaretic acid in antigen sensitized guinea pigs. Respiration Physiology and Neurobiology. 2016: 234:26-31.
Bergren, D.R. Modeling of rapidly-adapting pulmonary stretch receptors to lung inflation. In preparation.
Bergren, D.R. Effect of ether inhalation on rapidly-adapting pulmonary stretch receptors in guinea pigs. Respiration Physiology and Neurobiology Accepted with minor revisions 08/2019.
Bergren DR. "Respiratory physiology in health and disease" in Pulmonary rehabilitation: Guidelines to success, Eds. J Hodgkin, M.D., CW Bell, Ph.D., and G. Connors Lippincott Press, Philadelphia, PA. Chapter 25:443:477, copyright 1993.
Bergren DR. "Pulmonary reflex effect on airway smooth muscle and ventilation" in Airway smooth muscle: Modulation of receptors and response, Eds. DK Agrawal and RG Townley, CRC Press, Inc., Boca Raton, FL. Chapter 9:181-228, copyright 1990.
Environmental Statement, Big Sky Mine, Rosebud County, Montana, 1977. Appendix D-6. Potential human health effects.
Potential human health effects. Environment Statement, Spring Creek Mine, Big Horn County, Montana, 1977. Appendix D-4. Potential human health effects.
My research interests are directed towards identifying the mechanism of airway hyperirritability that develops after exposure to airway irritants such as tobacco smoke. This airway hyperirritability seems to be selective to an induced hyperirritability of sensory afferents in the airways, specifically bronchial and pulmonary C-fibers. Our recent research is designed to determine if the neuropeptide content of the lungs increase after irritant exposure. Neuropeptides are mediators synthesized and released by lung C-fibers. The airway hyperirritability is enhanced in sensitized airways. We therefore proposed to determine if the cells involved in airway hyperirritability such as the eosinophils and alveolar macrophages become hyperirritable after exposure to airway irritants such as tobacco smoke.
Most recently I have explored the possible role of mast cells extracellular matrix formation of pulmonary fibrosis. Tools that will be used are the mast cell degranulator Compound 48/80 and the mast cell stabilizer sodium cromoglyate.